Mums at high risk for developing pre-eclampsia have from as early at 12 weeks of pregnancy impaired heart function. This is also associated with delivering smaller babies.

Reference: Ling HZ, Guy GP, Bisquera A, Poon LC, Nicolaides KH, Kametas NA. Maternal hemodynamics in screenpositive and screennegative women of the ASPRE trial. Ultrasound in Obstetrics & Gynecology. 2019 Jul;54(1):51-7.